Vm24, a Natural Immunosuppressive Peptide, Potently and Selectively Blocks Kv1.3 Potassium Channels of Human T Cells

Blockade of Kv1.3 K(+) channels in T cells is a promising therapeutic approach for the treatment of autoimmune diseases such as multiple sclerosis and type 1 diabetes mellitus. Vm24 (α-KTx 23.1) is a novel 36-residue Kv1.3-specific peptide isolated from the venom of the scorpion Vaejovis mexicanus s...

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Autores principales: Varga, Zoltan, Gurrola-Briones, Georgina, Papp, Ferenc, Rodríguez de la Vega, Ricardo C., Pedraza-Alva, Gustavo, Tajhya, Rajeev B., Gaspar, Rezso, Cardenas, Luis, Rosenstein, Yvonne, Beeton, Christine, Possani, Lourival D., Panyi, Gyorgy
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2012
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422703/
https://ncbi.nlm.nih.gov/pubmed/22622363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.078006
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