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K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas
Pediatric glioblastomas (GBM) including diffuse intrinsic pontine gliomas (DIPG) are devastating brain tumors with no effective therapy. Here, we investigated clinical and biological impacts of histone H3.3 mutations. Forty-two DIPGs were tested for H3.3 mutations. Wild-type versus mutated (K27M-H3....
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3422615/ https://ncbi.nlm.nih.gov/pubmed/22661320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-012-0998-0 |
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