Targeted deletion of MyD88 in intestinal epithelial cells results in compromised antibacterial immunity associated with downregulation of polymeric immunoglobulin receptor, mucin-2, and antibacterial peptides

Intestinal epithelial cells (IECs) form a physical and immunological barrier that separates the vast gut microbiota from host tissues. MyD88-dependent Toll-like receptor signaling is a key mediator of microbial–host cross-talk. We examined the role of epithelial MyD88 expression by generating mice w...

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Autori principali: Frantz, A L, Rogier, E W, Weber, C R, Shen, L, Cohen, D A, Fenton, L A, Bruno, M E C, Kaetzel, C S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422608/
https://ncbi.nlm.nih.gov/pubmed/22491177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2012.23
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