The Soluble Guanylate Cyclase Stimulator Riociguat Ameliorates Pulmonary Hypertension Induced by Hypoxia and SU5416 in Rats

BACKGROUND: The nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) signal-transduction pathway is impaired in many cardiovascular diseases, including pulmonary arterial hypertension (PAH). Riociguat (BAY 63–2521) is a stimulator of sGC that works both in synergy...

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Autori principali: Lang, Michaela, Kojonazarov, Baktybek, Tian, Xia, Kalymbetov, Anuar, Weissmann, Norbert, Grimminger, Friedrich, Kretschmer, Axel, Stasch, Johannes-Peter, Seeger, Werner, Ghofrani, Hossein Ardeschir, Schermuly, Ralph Theo
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422306/
https://ncbi.nlm.nih.gov/pubmed/22912874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043433
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