The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA

Constitutive activation of pro-survival kinases has become a promising target of small molecules with an increasing interest in developing multi-targeted agents. The mechanisms underlying the responsiveness to most agents targeting cancer specific survival pathways are still poorly understood but cr...

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Detalhes bibliográficos
Main Authors: Sun, Jing, Sun, Quanhong, Brown, Matthew F., Dudgeon, Crissy, Chandler, Julie, Xu, Xiang, Shu, Yongqian, Zhang, Lin, Yu, Jian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3422222/
https://ncbi.nlm.nih.gov/pubmed/22912816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043158
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