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Chemical synthesis of 5'-pyrophosphate and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. CD study of the effect of 5'-phosphate groups on the conformation of 3'-5' GpG.

A simple, two-step method is described for the synthesis of the 5'-pyro- and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. The readily accessible 2'(3')-5' ApA, ApG, GpA and GpG were converted in one step to the corresponding 5'-phosphoramidate derivatives which were then transformed to t...

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Dettagli Bibliografici
Pubblicato in:Nucleic Acids Res
Autori principali: Tomasz, J, Simoncsits, A, Kajtár, M, Krug, R M, Shatkin, A J
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 1978
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC342217/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/211490/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/5.8.2945
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