Effect of Linezolid on the 50% Lethal Dose and 50% Protective Dose in Treatment of Infections by Gram-Negative Pathogens in Naive and Immunosuppressed Mice and on the Efficacy of Ciprofloxacin in an Acute Murine Model of Septicemia

Murine models of infection were used to study the effect of linezolid on the virulence of Gram-negative bacteria and to assess potential pharmacodynamic interactions with ciprofloxacin in the treatment of these infections, prompted by observations from a recent clinical trial. Naive and immunosuppre...

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Detalhes bibliográficos
Main Authors: Marra, Andrea, Lamb, Lucinda, Medina, Ivette, George, David, Gibson, Glenn, Hardink, Joel, Rugg, Jady, Van Deusen, Jeffrey, O'Donnell, John P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421840/
https://ncbi.nlm.nih.gov/pubmed/22710118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00276-12
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