An Epstein-Barr Virus (EBV) Mutant with Enhanced BZLF1 Expression Causes Lymphomas with Abortive Lytic EBV Infection in a Humanized Mouse Model

Immunosuppressed patients are at risk for developing Epstein-Barr Virus (EBV)-positive lymphomas that express the major EBV oncoprotein, LMP1. Although increasing evidence suggests that a small number of lytically infected cells may promote EBV-positive lymphomas, the impact of enhanced lytic gene e...

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Bibliographische Detailangaben
Hauptverfasser: Ma, Shi-Dong, Yu, Xianming, Mertz, Janet E., Gumperz, Jenny E., Reinheim, Erik, Zhou, Ying, Tang, Weihua, Burlingham, William J., Gulley, Margaret L., Kenney, Shannon C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421695/
https://ncbi.nlm.nih.gov/pubmed/22623780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00770-12
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