Application of a Loading Dose of Colistin Methanesulfonate in Critically Ill Patients: Population Pharmacokinetics, Protein Binding, and Prediction of Bacterial Kill

A previous pharmacokinetic study on dosing of colistin methanesulfonate (CMS) at 240 mg (3 million units [MU]) every 8 h indicated that colistin has a long half-life, resulting in insufficient concentrations for the first 12 to 48 h after initiation of treatment. A loading dose would therefore be be...

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Detalhes bibliográficos
Main Authors: Mohamed, Ami F., Karaiskos, Ilias, Plachouras, Diamantis, Karvanen, Matti, Pontikis, Konstantinos, Jansson, Britt, Papadomichelakis, Evangelos, Antoniadou, Anastasia, Giamarellou, Helen, Armaganidis, Apostolos, Cars, Otto, Friberg, Lena E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3421626/
https://ncbi.nlm.nih.gov/pubmed/22615285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06426-11
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