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Tigecycline Resistance Can Occur Independently of the ramA Gene in Klebsiella pneumoniae
Tigecycline resistance in Klebsiella pneumoniae results from ramA upregulation that causes the overexpression of the efflux pump, AcrAB-TolC. Tigecycline mutants, derived from Ecl8ΔramA, can exhibit a multidrug resistance phenotype due to increased transcription of the marA, rarA, acrAB, and oqxAB g...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3421586/ https://ncbi.nlm.nih.gov/pubmed/22644034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.06224-11 |
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