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MMS19 assembles iron-sulfur proteins required for DNA metabolism and genomic integrity

Instability of the nuclear genome is a hallmark of cancer and aging. MMS19 protein has been linked to maintenance of genomic integrity but the molecular basis of this connection is unknown. Here, we identify MMS19 as a member of the cytosolic iron-sulfur protein assembly (CIA) machinery. MMS19 funct...

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Библиографические подробности
Главные авторы: Stehling, Oliver, Vashisht, Ajay A., Mascarenhas, Judita, Jonsson, Zophonias O., Sharma, Tanu, Netz, Daili J.A., Pierik, Antonio J., Wohlschlegel, James A., Lill, Roland
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3420340/
https://ncbi.nlm.nih.gov/pubmed/22678362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1219723
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