KRAS mutation detection by high-resolution melting analysis significantly predicts clinical benefit of cetuximab in metastatic colorectal cancer

BACKGROUND: Anti-epidermal growth factor receptor (EGFR) monoclonal antibodies are restricted to KRAS wild-type (WT) metastatic colorectal cancers (mCRCs), usually identified by direct sequencing, that may yield false negative results because of genetic heterogeneity within the tumour. We evaluated...

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Detalhes bibliográficos
Main Authors: Malapelle, U, Carlomagno, C, Salatiello, M, De Stefano, A, De Luca, C, Bianco, R, Marciano, R, Cimminiello, C, Bellevicine, C, De Placido, S, Troncone, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Clinical Study
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419946/
https://ncbi.nlm.nih.gov/pubmed/22805329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.275
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