A novel µ-conopeptide, CnIIIC, exerts potent and preferential inhibition of Na(V)1.2/1.4 channels and blocks neuronal nicotinic acetylcholine receptors

BACKGROUND AND PURPOSE: The µ-conopeptide family is defined by its ability to block voltage-gated sodium channels (VGSCs), a property that can be used for the development of myorelaxants and analgesics. We characterized the pharmacology of a new µ-conopeptide (µ-CnIIIC) on a range of preparations an...

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Favreau, Philippe, Benoit, Evelyne, Hocking, Henry G, Carlier, Ludovic, D' hoedt, Dieter, Leipold, Enrico, Markgraf, René, Schlumberger, Sébastien, Córdova, Marco A, Gaertner, Hubert, Paolini-Bertrand, Marianne, Hartley, Oliver, Tytgat, Jan, Heinemann, Stefan H, Bertrand, Daniel, Boelens, Rolf, Stöcklin, Reto, Molgó, Jordi
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Blackwell Publishing Ltd 2012
Θέματα:
Research Papers
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419909/
https://ncbi.nlm.nih.gov/pubmed/22229737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2012.01837.x
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