Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms...

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Bibliografski detalji
Glavni autori: Russell, Claire L., Semerdjieva, Sophia, Empson, Ruth M., Austen, Brian M., Beesley, Philip W., Alifragis, Pavlos
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419646/
https://ncbi.nlm.nih.gov/pubmed/22905234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043201
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