Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms...

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Detalhes bibliográficos
Main Authors: Russell, Claire L., Semerdjieva, Sophia, Empson, Ruth M., Austen, Brian M., Beesley, Philip W., Alifragis, Pavlos
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419646/
https://ncbi.nlm.nih.gov/pubmed/22905234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043201
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