Amyloid-β Acts as a Regulator of Neurotransmitter Release Disrupting the Interaction between Synaptophysin and VAMP2

BACKGROUND: It is becoming increasingly evident that deficits in the cortex and hippocampus at early stages of dementia in Alzheimer’s disease (AD) are associated with synaptic damage caused by oligomers of the toxic amyloid-β peptide (Aβ42). However, the underlying molecular and cellular mechanisms...

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Bibliographic Details
Main Authors: Russell, Claire L., Semerdjieva, Sophia, Empson, Ruth M., Austen, Brian M., Beesley, Philip W., Alifragis, Pavlos
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419646/
https://ncbi.nlm.nih.gov/pubmed/22905234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043201
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