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Lipid-dependent effects of halothane on gramicidin channel kinetics: A new role for lipid packing stress
We find that the sensitivity of gramicidin A channels to the anesthetic halothane is highly lipid dependent. Specifically, exposure of membranes made of lamellar DOPC to halothane in concentrations close to clinically relevant reduces channel life-times by an order of magnitude. At the same time, gr...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3419375/ https://ncbi.nlm.nih.gov/pubmed/19405539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900494y |
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