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Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation

BRCA1, a product of a familial breast and ovarian cancer susceptibility gene, localizes to centrosomes and physically interacts with γ-tubulin, a key centrosomal protein for microtubule nucleation and anchoring at centrosomes. Here, we performed a rigorous analysis of centrosome localization of BRCA...

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Bibliographic Details
Main Authors: Tarapore, Pheruza, Hanashiro, Kazuhiko, Fukasawa, Kenji
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3419063/
https://ncbi.nlm.nih.gov/pubmed/22833046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.21396
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