Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts

In this study, we determined the molecular mechanism of γ-tocotrienol (GTT) in preventing cellular aging by focusing on its anti-apoptotic effect in stress-induced premature senescence (SIPS) model of human diploid fibroblasts (HDFs). Results obtained showed that SIPS exhibited senescent-phenotypic...

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Bibliographic Details
Main Authors: Makpol, Suzana, Abdul Rahim, Norhazira, Kien Hui, Chua, Wan Ngah, Wan Zurinah
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418699/
https://ncbi.nlm.nih.gov/pubmed/22919441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/785743
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