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Tanespimycin with bortezomib: activity in relapsed/refractory patients with multiple myeloma

Tanespimycin (17-allylamino-17-demethoxygeldanamycin, 17-AAG) disrupts heat shock protein 90 (HSP90), a key molecular chaperone for signal transduction proteins critical to myeloma growth, survival and drug resistance. In previous studies, tanespimycin monotherapy was well tolerated and active in he...

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Dettagli Bibliografici
Autori principali: Richardson, Paul G., Badros, Ashraf Z., Jagannath, Sundar, Tarantolo, Stefano, Wolf, Jeffrey L., Albitar, Maher, Berman, David, Messina, Marianne, Anderson, Kenneth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418598/
https://ncbi.nlm.nih.gov/pubmed/20618338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2141.2010.08264.x
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