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Structure of AAV-DJ, a Retargeted Gene Therapy Vector: Cryo-Electron Microscopy at 4.5Å resolution
AAV-DJ, a leading candidate vector for liver gene therapy, was created through random homologous recombination followed by directed evolution, selecting for in vivo liver tropism and resistance to in vitro immune neutralization. Here, the 4.5Å resolution cryo-EM structure is determined, the first fo...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3418430/ https://ncbi.nlm.nih.gov/pubmed/22727812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2012.05.004 |
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