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Betulinic acid decreases ER-negative breast cancer cell growth in vitro and in vivo: role of Sp transcription factors and microRNA-27a:ZBTB10

Betulinic acid (BA), a pentacyclic triterpenoid isolated from tree bark is cytotoxic to cancer cells. There is evidence that specificity proteins (Sps), such as Sp1, Sp3 and Sp4, are overexpressed in tumors and contribute to the proliferative and angiogenic phenotype associated with cancer cells. Th...

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Bibliografski detalji
Glavni autori: Mertens-Talcott, Susanne U., Noratto, Giuliana D., Li, Xiangrong, Angel-Morales, Gabriela, Bertoldi, Michele C., Safe, Stephen
Format: Artigo
Jezik:Inglês
Izdano: 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418350/
https://ncbi.nlm.nih.gov/pubmed/22407812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.21893
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