SERPINA1 PiZ and PiS Heterozygotes and Lung Function Decline in the SAPALDIA Cohort

BACKGROUND: Severe alpha1-antitrypsin (AAT) deficiency is a strong risk factor for COPD. But the impact of gene variants resulting in mild or intermediate AAT deficiency on the longitudinal course of respiratory health remains controversial. There is indication from experimental studies that pro-inf...

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Main Authors: Thun, Gian-Andri, Ferrarotti, Ilaria, Imboden, Medea, Rochat, Thierry, Gerbase, Margaret, Kronenberg, Florian, Bridevaux, Pierre-Olivier, Zemp, Elisabeth, Zorzetto, Michele, Ottaviani, Stefania, Russi, Erich W., Luisetti, Maurizio, Probst-Hensch, Nicole M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418297/
https://ncbi.nlm.nih.gov/pubmed/22912729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042728
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