Silencing of GPNMB by siRNA Inhibits the Formation of Melanosomes in Melanocytes in a MITF-Independent Fashion

BACKGROUND: Melanosomes are specialized membrane-surrounded organelles, which are involved in the synthesis, storage and transport of melanin. Glycoprotein (transmembrane) non-metastatic melanoma protein b (GPNMB), a melanosome-specific structural protein, shares significant amino acid sequence homo...

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Detalhes bibliográficos
Main Authors: Zhang, Ping, Liu, Wei, Zhu, Cansheng, Yuan, Xiaoying, Li, Dongguang, Gu, Weijie, Ma, Huimin, Xie, Xin, Gao, Tianwen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418242/
https://ncbi.nlm.nih.gov/pubmed/22912767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042955
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