TAp63 prevents premature aging by promoting adult stem cell maintenance

The cellular mechanisms that regulate the maintenance of adult tissue stem cells are still largely unknown. We show here that the p53 family member, TAp63, is essential for maintenance of epidermal and dermal precursors and that, in its absence, these precursors senesce and skin ages prematurely. Sp...

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Main Authors: Su, Xiaohua, Paris, Maryline, Gi, Young Jin, Tsai, Kenneth Y., Cho, Min Soon, Lin, Yu-Li, Biernaskie, Jeffrey A., Sinha, Satrajit, Prives, Carol, Pevny, Larysa H., Miller, Freda D., Flores, Elsa R.
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418222/
https://ncbi.nlm.nih.gov/pubmed/19570515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2009.04.003
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