T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α

Expression and function of the antigen T cell receptor (TCR) play a central role in regulating immune responsiveness. Accordingly, targeting the expression of TCRαβ or its associated CD3 subunits profoundly influences T cell development and adaptive immunity. Down-regulation of the invariant TCRζ ch...

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Bibliografske podrobnosti
Main Authors: Clark, Joanna M., Annenkov, Alexander E., Panesar, Manvinder, Isomäki, Pia, Chernajovsky, Yuti, Cope, Andrew P.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2004
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC341820/
https://ncbi.nlm.nih.gov/pubmed/14745016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308231100
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