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T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α
Expression and function of the antigen T cell receptor (TCR) play a central role in regulating immune responsiveness. Accordingly, targeting the expression of TCRαβ or its associated CD3 subunits profoundly influences T cell development and adaptive immunity. Down-regulation of the invariant TCRζ ch...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC341820/ https://ncbi.nlm.nih.gov/pubmed/14745016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308231100 |
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