T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α

Expression and function of the antigen T cell receptor (TCR) play a central role in regulating immune responsiveness. Accordingly, targeting the expression of TCRαβ or its associated CD3 subunits profoundly influences T cell development and adaptive immunity. Down-regulation of the invariant TCRζ ch...

Full description

Saved in:
Bibliographic Details
Main Authors: Clark, Joanna M., Annenkov, Alexander E., Panesar, Manvinder, Isomäki, Pia, Chernajovsky, Yuti, Cope, Andrew P.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC341820/
https://ncbi.nlm.nih.gov/pubmed/14745016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308231100
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items