Intranasal Administration of PACAP: Uptake by Brain and Brain Region Targeting with Cyclodextrins

Pituitary adenylate cyclase activating polypeptide (PACAP) is a potent neurotrophic and neuroprotectant that is transported across the blood-brain barrier in amounts sufficient to affect brain function. However, its short half-life in blood makes it difficult to administer peripherally. Here, we det...

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Bibliographic Details
Main Authors: Nonaka, Naoko, Farr, Susan A., Nakamachi, Tomoya, Morley, John E., Nakamura, Masanori, Shioda, Seiji, Banks, William A.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418062/
https://ncbi.nlm.nih.gov/pubmed/22687366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2012.05.021
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