The Ca(2+)-stimulated adenylyl cyclase AC1 generates efficient biological pacing as single gene therapy and in combination with HCN2

BACKGROUND: Biological pacing performed solely via HCN2 gene transfer in vivo results in relatively slow idioventricular rates and only moderate autonomic responsiveness. We induced biological pacing using the Ca(2+)-stimulated adenylyl cyclase AC1 gene expressed alone or in combination with HCN2 an...

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Hlavní autoři: Boink, Gerard J. J., Nearing, Bruce D., Shlapakova, Iryna N., Duan, Lian, Kryukova, Yelena, Bobkov, Eugene, Tan, Hanno L., Cohen, Ira S., Danilo, Peter, Robinson, Richard B., Verrier, Richard L., Rosen, Michael R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3418050/
https://ncbi.nlm.nih.gov/pubmed/22753192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.111.083584
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