Myxobacteria vs. Sponge-Derived Alkaloids: The Bengamide Family Identified as Potent Immune Modulating Agents by Scrutiny of LC-MS/ELSD Libraries

A nuclear factor-κB (NF-κB) luciferase assay has been employed to identify the bengamides, previously known for their anti-tumor activity, as a new class of immune modulators. A unique element of this study was that the bengamide analogs were isolated from two disparate sources, Myxococcus virescens...

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Detalhes bibliográficos
Main Authors: Johnson, Tyler A., Sohn, Johann, Vaske, Yvette M., White, Kimberly N., Cohen, Tanya L., Vervoort, Helene C., Tenney, Karen, Valeriote, Frederick A., Bjeldanes, Leonard F., Crews, Phillip
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417756/
https://ncbi.nlm.nih.gov/pubmed/22705020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.05.043
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