Differential inhibition of tumour cell-induced platelet aggregation by the nicotinate aspirin prodrug (ST0702) and aspirin

BACKGROUND AND PURPOSE: Tumour cell-induced platelet aggregation (TCIPA) facilitates cancer cell invasion, angiogenesis and the formation of metastatic foci. TCIPA can be modulated by pharmacological inhibitors of MMP-2 and ADP; however, the COX inhibitor aspirin did not prevent TCIPA. In this study...

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Bibliographic Details
Main Authors: Medina, Carlos, Harmon, Shona, Inkielewicz, Iwona, Santos-Martinez, Maria Jose, Jones, Michael, Cantwell, Paula, Bazou, Despina, Ledwidge, Mark, Radomski, Marek W, Gilmer, John F
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2012
Subjects:
Research Papers
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417420/
https://ncbi.nlm.nih.gov/pubmed/22122360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01794.x
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