Increased soluble urokinase plasminogen activator receptor (suPAR) is associated with thrombosis and inhibition of plasmin generation in paroxysmal nocturnal hemoglobinuria (PNH) patients

Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired genetic disorder of the bone marrow that produces intravascular hemolysis, proclivity to venous thrombosis, and hematopoietic failure. Mutation in the PIG-A gene of a hematopoietic stem cell abrogates synthesis of glycosylphosphoinositol (GPI)...

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Bibliografiske detaljer
Main Authors: Sloand, Elaine M, Pfannes, Loretta, Scheinberg, Phillip, More, Kenneth, Wu, Colin O, Horne, McDonald, Young, Neal S
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417356/
https://ncbi.nlm.nih.gov/pubmed/18954937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2008.06.016
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