Reprogramming liver-stem WB cells into functional insulin-producing cells by persistent expression of Pdx1- and Pdx1-VP16 mediated by lentiviral vectors

Adenovirus-mediated transient expression of the pancreatic duodenal homeobox transcription factor Pdx1 in mouse liver activates pancreatic endocrine and exocrine genes, the latter reportedly resulting in severe hepatitis. Expression of a super-active form of Pdx1 or Pdx1-VP16 selectively transdiffer...

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Bibliographic Details
Main Authors: Tang, Dong-Qi, Lu, Shun, Sun, Yu-Ping, Rodrigues, Enda, Chou, Wayne, Yang, Cheryl, Cao, Li-Zhen, Chang, Lung-Ji, Yang, Li-Jun
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417286/
https://ncbi.nlm.nih.gov/pubmed/16294197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.3700368
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