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LBH589 enhances T-cell activation in vivo and accelerates graft-versus-host disease in mice
Histone deacetylase inhibitors (HDACi) are a new class of compounds that induce acetylation of histone lysine tails in chromatin and modify gene expression. The FDA approved HDACi, Vorinostat or suberoylanilide hydroxamic acid (SAHA), has been shown to inhibit tumor cell growth and the production of...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3417119/ https://ncbi.nlm.nih.gov/pubmed/22698484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbmt.2012.06.002 |
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