Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1

Artemisinin and its main active metabolite dihydroartemisinin, clinically used antimalarial agents with low host toxicity, have recently shown potent anticancer activities in a variety of human cancer models. Although iron mediated oxidative damage is involved, the mechanisms underlying these activi...

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Detalhes bibliográficos
Main Authors: Ba, Qian, Zhou, Naiyuan, Duan, Juan, Chen, Tao, Hao, Miao, Yang, Xinying, Li, Junyang, Yin, Jun, Chu, Ruiai, Wang, Hui
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416848/
https://ncbi.nlm.nih.gov/pubmed/22900042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042703
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