Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells

AIMS: The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer (PC) is known, however, its mechanism is unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic...

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Detalhes bibliográficos
Main Authors: Xu, Xuanfu, Zhou, Yingqun, Xie, Chuangao, Wei, Shu-mei, Gan, Huizhong, He, Shengli, Wang, Fan, Xu, Ling, Lu, Jie, Dai, Weiqi, He, Lei, Chen, Ping, Wang, Xingpeng, Guo, Chuanyong
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416762/
https://ncbi.nlm.nih.gov/pubmed/22900095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043119
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