Genome-Wide Screening Reveals an EMT Molecular Network Mediated by Sonic Hedgehog-Gli1 Signaling in Pancreatic Cancer Cells

AIMS: The role of sonic hedgehog (SHH) in epithelial mesenchymal transition (EMT) of pancreatic cancer (PC) is known, however, its mechanism is unclear. Because SHH promotes tumor development predominantly through Gli1, we sought to understand its mechanism by identifying Gli1 targets in pancreatic...

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Autors principals: Xu, Xuanfu, Zhou, Yingqun, Xie, Chuangao, Wei, Shu-mei, Gan, Huizhong, He, Shengli, Wang, Fan, Xu, Ling, Lu, Jie, Dai, Weiqi, He, Lei, Chen, Ping, Wang, Xingpeng, Guo, Chuanyong
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416762/
https://ncbi.nlm.nih.gov/pubmed/22900095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043119
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