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A Gain-of-Function Mutation in Gating of Corynebacterium glutamicum NCgl1221 Causes Constitutive Glutamate Secretion

The A-to-V mutation at position 111 (A111V) in the mechanosensitive channel NCgl1221 (MscCG) causes constitutive glutamate secretion in Corynebacterium glutamicum. Patch clamp experiments revealed that NCgl1221 (A111V) had a significantly smaller gating threshold than the wild-type counterpart and d...

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Detalhes bibliográficos
Main Authors: Nakayama, Yoshitaka, Yoshimura, Kenjiro, Iida, Hidetoshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416442/
https://ncbi.nlm.nih.gov/pubmed/22610427
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.01310-12
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