Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

The hepatitis C virus (HCV) NS5B protein is an RNA-dependent RNA polymerase essential for replication of the viral RNA genome. In vitro and presumably in vivo, NS5B initiates RNA synthesis by a de novo mechanism and then processively copies the whole RNA template. Dissections of de novo RNA synthesi...

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Detalhes bibliográficos
Main Authors: Scrima, Nathalie, Caillet-Saguy, Célia, Ventura, Michel, Harrus, Déborah, Astier-Gin, Thérèse, Bressanelli, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416344/
https://ncbi.nlm.nih.gov/pubmed/22532694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00459-12
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