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Splice-Mediated Motif Switching Regulates Disabled-1 Phosphorylation and SH2 Domain Interactions
Disabled-1 (Dab1) plays a key role in reelin-mediated neuronal migration during brain development. Tyrosine phosphorylation of Dab1 at two YQXI and two YXVP motifs recruits multiple SH2 domains, resulting in activation of a wide range of signaling cascades. However, the molecular mechanisms underlyi...
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| Main Authors: | , , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2012
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3416185/ https://ncbi.nlm.nih.gov/pubmed/22586277 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00570-12 |
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