Splice-Mediated Motif Switching Regulates Disabled-1 Phosphorylation and SH2 Domain Interactions

Disabled-1 (Dab1) plays a key role in reelin-mediated neuronal migration during brain development. Tyrosine phosphorylation of Dab1 at two YQXI and two YXVP motifs recruits multiple SH2 domains, resulting in activation of a wide range of signaling cascades. However, the molecular mechanisms underlyi...

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Main Authors: Gao, Zhihua, Poon, Ho Yin, Li, Lei, Li, Xiaodong, Palmesino, Elena, Glubrecht, Darryl D., Colwill, Karen, Dutta, Indrani, Kania, Artur, Pawson, Tony, Godbout, Roseline
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2012
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416185/
https://ncbi.nlm.nih.gov/pubmed/22586277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00570-12
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