Nontypeable Pneumococcal Isolates Among Navajo and White Mountain Apache Communities: Are These Really a Cause of Invasive Disease?

Background. Pneumococci could evade pneumococcal conjugate vaccines (PCV) by modifying, mutating, or deleting vaccine-serotype capsule genes or by downregulating capsule production. We sought to assess whether pneumococci that are nontypeable (NT) by the Quellung reaction truly lack capsule genes or...

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Autors principals: Scott, Jennifer R., Hinds, Jason, Gould, Katherine A., Millar, Eugene V., Reid, Raymond, Santosham, Mathuram, O'Brien, Katherine L., Hanage, William P.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2012
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415932/
https://ncbi.nlm.nih.gov/pubmed/22536000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jis307
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