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Ablation of TNAP function compromises myelination and synaptogenesis in the mouse brain
Mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene can result in skeletal and dental hypomineralization and severe neurological symptoms. TNAP is expressed in the synaptic cleft and the node of Ranvier in normal adults. Using TNAP knockout (KO) mice (Akp2(−/−)), we studied synaptog...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415568/ https://ncbi.nlm.nih.gov/pubmed/22696173 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00441-012-1455-z |
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