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Functional Specificity of a Protein-DNA Complex Mediated by Two Arginines Bound to the Minor Groove

A bacteriophage Ø29 transcriptional regulator, protein p4, interacts with its DNA target by employing two mechanisms: by direct readout of the chemical signatures of only one DNA base and by inducing local modification on the topology of short A tracts (indirect readout). p4 binds as a dimer to targ...

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Détails bibliographiques
Auteurs principaux: Mendieta, Jesús, Pérez-Lago, Laura, Salas, Margarita, Camacho, Ana
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415518/
https://ncbi.nlm.nih.gov/pubmed/22753063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00677-12
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