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Strained Cyclophane Macrocycles: Impact of Progressive Ring Size Reduction on Synthesis and Structure
The synthesis, X-ray crystal structures, and calculated strain energies are reported for a homologous series of 11- to 14-membered drug-like cyclophane macrocycles, representing an unusual region of chemical space that can be difficult to access synthetically. The ratio of macrocycle to dimer, gener...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3415328/ https://ncbi.nlm.nih.gov/pubmed/22133103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja208503y |
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