Prenatal Ablation of Nicotinic Receptor alpha7 Cell Lineages Produces Lumbosacral Spina Bifida the Severity of Which is Modified by Choline and Nicotine Exposure

Lumbosacral spina bifida is a common debilitating birth defect whose multiple causes are poorly understood. Here, we provide the first genetic delineation of cholinergic nicotinic receptor alpha7 (Chrna7) expression and link the ablation of the Chrna7 cell lineage to this condition in the mouse. Usi...

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Autores principales: Rogers, Scott W, Tvrdik, Petr, Capecchi, Mario R, Gahring, Lorise C
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2012
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3415211/
https://ncbi.nlm.nih.gov/pubmed/22473653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.a.35372
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