Binding of Congo Red to Amyloid Protofibrils of the Alzheimer Aβ(9–40) Peptide Probed by Molecular Dynamics Simulations

Congo red (CR) is a commonly used histological amyloid dye and a weak amyloid inhibitor. There is currently no experimentally available structure of CR bound to an amyloid fibril and the binding modes, and the mechanisms governing its inhibitory and optical properties are poorly understood. In this...

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Библиографические подробности
Главные авторы: Wu, Chun, Scott, Justin, Shea, Joan-Emma
Формат: Artigo
Язык:Inglês
Опубликовано: The Biophysical Society 2012
Предметы:
Proteins and Nucleic Acids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414877/
https://ncbi.nlm.nih.gov/pubmed/22947871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.07.008
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