Ethanol and Hepatitis C Virus Suppress Peptide-MHC Class I Presentation In Hepatocytes By Altering Proteasome Function

BACKGROUND AND AIMS: Previously, we reported that exposure of hepatitis C virus (HCV) core expressing ethanol-metabolizing cells to ethanol significantly suppresses proteasome activity which exists as 26S (20S and 19S) and as an unassociated 20S particle. The replacement of the constitutive proteaso...

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Bibliographic Details
Main Authors: Osna, Natalia A., Bardag-Gorce, Fawzia, White, Ronda L., Weinman, Steven A., Donohue, Terrence M., Kharbanda, Kusum K.
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414636/
https://ncbi.nlm.nih.gov/pubmed/22551112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2012.01813.x
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