Growth Factor-Activated Stem Cell Circuits and Stromal Signals Cooperatively Accelerate Non-Integrated iPSC Reprogramming of Human Myeloid Progenitors

Nonviral conversion of skin or blood cells into clinically useful human induced pluripotent stem cells (hiPSC) occurs in only rare fractions (∼0.001%–0.5%) of donor cells transfected with non-integrating reprogramming factors. Pluripotency induction of developmentally immature stem-progenitors is ge...

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Bibliographische Detailangaben
Hauptverfasser: Park, Tea Soon, Huo, Jeffrey S., Peters, Ann, Talbot, C. Conover, Verma, Karan, Zimmerlin, Ludovic, Kaplan, Ian M., Zambidis, Elias T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414503/
https://ncbi.nlm.nih.gov/pubmed/22905176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042838
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