Molecular Resistance Fingerprint of Pemetrexed and Platinum in a Long-Term Survivor of Mesothelioma

BACKGROUND: Pemetrexed, a multi-folate inhibitor combined with a platinum compound is the first-line treatment of malignant mesothelioma, but median survival is still one year. Intrinsic and acquired resistance to pemetrexed is common, but its biological basis is obscure. Here we report for the firs...

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Hlavní autoři: Røe, Oluf Dimitri, Szulkin, Adam, Anderssen, Endre, Flatberg, Arnar, Sandeck, Helmut, Amundsen, Tore, Erlandsen, Sten Even, Dobra, Katalin, Sundstrøm, Stein Harald
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414492/
https://ncbi.nlm.nih.gov/pubmed/22905093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040521
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