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Effects of Disulfide Bond Formation and Protein Helicity on the Aggregation of Activating Transcription Factor 5 (ATF5)

Amorphous aggregation is a major problem for protein biopharmaceuticals, and aggregate formation in a drug formulation can have serious health implications for the patient. In many cases, an immunogenic response is generated from the administration of a drug product containing aggregated protein. Th...

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Hlavní autoři: Ciaccio, Natalie A., Laurence, Jennifer S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3414431/
https://ncbi.nlm.nih.gov/pubmed/19435374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900058t
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